Fillerina, which Labo has been working on since 2007 (the year the trademark was registered), is a dermocosmetic filling preparation for at-home use: it works in such a way as to be presented as a cosmetic filling treatment for at-home use and to be applied externally. The product name comes from the filling mechanism of face depressions and from the volumizing mechanism of specific zones, thanks to the action of special Hyaluronic Acids with different molecular weights for a different level of filling of expression lines, age wrinkles and furrows, microrelief and areas of the face subject to emptying and loss of volume (cheekbones, face shape, lips surface). This set contains: - 14 doses (2 ml each) of Biorevitalizing Filler Gel - 14 doses (2 ml each) of Bio-Revitalizing Nourishing Film - 2x precision applicators for external use - 1x Pre-Fillerina 50ml + 1x Pre-Fillerina brush Designed for: - For skin depressions (age wrinkles and expression lines) - For the oval of the face - For the volume of cheekbones and lips - For improving the appearance of glabellar and naso-labial furrows and lip contour wrinkles - For skin biorevitalization - For enhancing skin density and plasticity. FILLER EFFECT As skin ages, the amount of Hyaluronic Acid gradually decreases, causing imperfections such as age wrinkles, expression lines and a loss of volume (emptying and skin depressions), especially on cheekbones, cheeks and lips. Fillerina 932 Biorevitalizing features a mix of 9 different Hyaluronic Acid molecules with varying molecular weights and sizes that are particularly effective at penetrating the layers of the skin (ex vivo test with Franz Cells), thus allowing tissues to be filled in and plumped up. Among the Hyaluronic Acids with filler effect, the new 100000 Da molecular weight Hyaluronic Acid molecule resulted in a great penetration capability. SUPER-DENSITY EFFECT Another serious aspect of skin ageing process is the impoverishment of an indispensable substance for skin support: Collagen, a protein that is strongly responsible for the mechanical properties of biological tissues. The loss and decrease of Collagen quantity in the skin translate into a reduced thickness and density and a subsequent increase in the number of wrinkles, skin depressions and a greater loss of volume. Fillerina 932 Biorevitalizing associates 3 Collagen molecules with different molecular weights (2000, 12000 and 300000 Da) which, thanks to their penetration in the skin (ex vivo test with Franz Cells), can promote a redensifying effect and improve the filler effect, in combination with Hyaluronic Acid molecules. PLASTICITY EFFECT Skin elasticity is the capability of the skin to deform under the action of external forces and resume its shape when forces cease. Elastic fibers, by wrapping and connecting collagen fibers up, allow the skin to return to its starting shape after compression or relaxation. With the passing of time also the quantity and quality of elastin, the protein that makes up elastic fibres, drastically decreases thus threatening skin plasticity and contributing to skin sagging. Fillerina 932 Biorevitalizing associates 2 molecules of Elastin with different molecular weights (1400 Da and 2200 Da), which help restore skin elasticity and plasticity. BIOREVITALIZING EFFECT Besides Hyaluronic Acids, for a replenishing effect, Collagen and Elastin molecules, Fillerina 932 Biorevitalizing contains all necessary components for the vitality of the skin, which experiences, as time goes by, a drastic reduction in physiological processes, typical of an old skin. The Biorevitalizing Complex contains 20 amino acids, 11 vitamins, 6 trace elements and 2 nucleic acids: their great penetration capability has been ex vivo tested by means of Franz Cells and depends on their low molecular weight. Thanks to this important feature, these substances can penetrate both epidermis and dermis (see table) thus giving the skin brightness, compactness, smoothness and splendor. The molecular weight of the 20 amino acids ranges from 75 to 204 Dalton; that of the 11 vitamins (vit. A, C, E and B-Group) ranges from 122 to 1500 Dalton; the 6 trace elements (Calcium, Iron, Magnesium, Manganese, Copper and Zinc) have a molecular weight ranging from 95 to 162 Dalton; finally, the molecular weight of the 2 nucleic acids, Hydrolyzed DNA and RNA, is 660 and 330 Dalton respectively. The Biorevitalizing Complex is contained in both Filler Gel and Nourishing Film. THE GRADES Fillerina 932 Biorevitalizing dermo-cosmetic filler treatments for at-home use have been formulated in 3 different concentrations (-Bio) containing differentiated blends of 9 Hyaluronic Acid molecules, 3 Collagens, 2 Elastins and of the Biorevitalizing Complex, to be chosen according to the individual needs. - GRADE 3-Bio: Visible wrinkles and expression lines. Age wrinkles with marked and uneven microrelief. Skin with inadequate thickness, density and plasticity. Dull complexion, damaged skin. - GR